Illicit drug use and its direct impact on workplace safety continues to be a growing issue. With a staggering surge in overdose deaths, reaching 98,000 in 2021—an alarming 58% increase from just two years ago—the current drug landscape demands urgent attention. Drug testing methodologies, such as urine analysis, hair testing, and oral fluid testing, play pivotal roles within comprehensive testing programs. Additionally, it stresses the critical importance of understanding state laws and regulations across different regions.