The Department of Transportation, understandably, creates strict guidelines for its employees relating to workplace safety that continue to change with regard to the evolution of drug use. Although marijuana, in certain states, and prescription drugs are legal, the DOT regulations remain stringent. This session will cover the significant updates in DOT regulations. We will address the issue of use vs abuse, along with the age of prescriptions, and a review of safety concerns from the MRO. Additionally, we will discuss the Medical Disclosure policies for both DOT and non-DOT.