As the COVID-19 pandemic takes center stage, crises such as the amphetamine epidemic only continue to worsen as they go unnoticed. Before the pandemic, amphetamines were already on the rise, and with added stress, anxiety, and fear, drug test positivity rates are now soaring. The pandemic has exacerbated conditions that lead people to self-medicate to help cope with the emotions that come along with unemployment, financial and health issues, and lockdowns. In addition, some individuals refrained from seeking treatment centers out of fear of contracting the virus. Others had trouble finding facilities that were open, as they limited services or closed. As we face one pandemic, employers need to anticipate the worsening amphetamine epidemic and prepare their workplace drug testing programs now before it’s too late.